Characterization and antiproliferative activity of nobiletin-loaded chitosan nanoparticles

Ana G. Luque-Alcaraz; Jaime Lizardi; Francisco M. Goycoolea; Miguel A. Valdez; Ana L. Acosta; Simon B. Iloki-Assanga; Inocencio Higuera-Ciapara; Waldo Argüelles-Monal

doi:10.1155/2012/265161

Characterization and antiproliferative activity of nobiletin-loaded chitosan nanoparticles

Ana G. Luque-Alcaraz, Jaime Lizardi, Francisco M. Goycoolea, Miguel A. Valdez, Ana L. Acosta, Simon B. Iloki-Assanga, Inocencio Higuera-Ciapara, Waldo Argüelles-Monal

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect. In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed. This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity. The association and loading efficiencies are 69.1 and 7.0, respectively. The formation of an imine bond between chitosan amine groups and the carbonyl group of nobiletin, via Schiff-base, is proposed. Nobiletin-loaded chitosan nanoparticles exhibit considerable inhibition (I C 50 = 8 μg/mL) of cancerous cells, revealing their great potential for applications in cancer chemotherapy.

Original language	English
Article number	265161
Journal	Journal of Nanomaterials
Volume	2012
DOIs	https://doi.org/10.1155/2012/265161
State	Published - 30 Oct 2012
Externally published	Yes

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title = "Characterization and antiproliferative activity of nobiletin-loaded chitosan nanoparticles",

abstract = "Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect. In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed. This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity. The association and loading efficiencies are 69.1 and 7.0, respectively. The formation of an imine bond between chitosan amine groups and the carbonyl group of nobiletin, via Schiff-base, is proposed. Nobiletin-loaded chitosan nanoparticles exhibit considerable inhibition (I C 50 = 8 μg/mL) of cancerous cells, revealing their great potential for applications in cancer chemotherapy.",

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T1 - Characterization and antiproliferative activity of nobiletin-loaded chitosan nanoparticles

AU - Luque-Alcaraz, Ana G.

AU - Lizardi, Jaime

AU - Goycoolea, Francisco M.

AU - Valdez, Miguel A.

AU - Acosta, Ana L.

AU - Iloki-Assanga, Simon B.

AU - Higuera-Ciapara, Inocencio

AU - Argüelles-Monal, Waldo

PY - 2012/10/30

Y1 - 2012/10/30

N2 - Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect. In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed. This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity. The association and loading efficiencies are 69.1 and 7.0, respectively. The formation of an imine bond between chitosan amine groups and the carbonyl group of nobiletin, via Schiff-base, is proposed. Nobiletin-loaded chitosan nanoparticles exhibit considerable inhibition (I C 50 = 8 μg/mL) of cancerous cells, revealing their great potential for applications in cancer chemotherapy.

AB - Nobiletin is a polymethoxyflavonoid with a remarkable antiproliferative effect. In order to overcome its low aqueous solubility and chemical instability, the use of nanoparticles as carriers has been proposed. This study explores the possibility of binding nobiletin to chitosan nanoparticles, as well as to evaluate their antiproliferative activity. The association and loading efficiencies are 69.1 and 7.0, respectively. The formation of an imine bond between chitosan amine groups and the carbonyl group of nobiletin, via Schiff-base, is proposed. Nobiletin-loaded chitosan nanoparticles exhibit considerable inhibition (I C 50 = 8 μg/mL) of cancerous cells, revealing their great potential for applications in cancer chemotherapy.

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VL - 2012

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Characterization and antiproliferative activity of nobiletin-loaded chitosan nanoparticles

Abstract

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