Chronic intestinal pseudo-obstruction: Clinical and manometric characteristics in the Chilean population

Edith Pérez de Arce, Glauben Landskron, Sandra Hirsch, Carlos Defilippi, Ana María Madrid

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background/Aims Chronic intestinal pseudo-obstruction (CIPO) is a rare syndrome characterized by a failure of the propulsion of intraluminal contents and recurrent symptoms of partial bowel obstruction in the absence of mechanical obstruction. Regional variations of the intestinal compromise have been described. Intestinal manometry can indicate the pathophysiology and prognosis. Our objective is to establish the demographic and clinical characteristics of group Chilean patients and analyze the motility of the small intestine and its prognostic value. Methods Patients with symptoms of intestinal pseudo-obstruction with dilated bowel loops were included, in all of whom a manometry of the small intestine was performed using perfused catheters. Results Of the 64 patients included, 51 women (average age 41.5 ± 17.6 years), 54 primary and 10 secondary CIPO were included. Dilatation of the small intestine was the only finding in 38 patients; in the remaining, the compromise was associated with other segments, primarily the colon. Forty-nine patients underwent 65 surgeries, mainly exploratory laparotomies and colectomies. Intestinal manometry was performed on all patients; 4 "patterns" were observed: neuropathic (n = 26), myopathic (n = 3), mixed (n = 24), and a group without motor activity (n = 11). The most relevant findings were the complex migrating motor disorders and decreased frequency and propagation of contractions. The 9 patients who died had a severe myopathic compromise. Conclusions In our series, isolated small bowel compromise was the most common disorder. Neuropathic motor compromise was observed in most of the patients. Mortality was associated with severe myopathic compromise.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalJournal of Neurogastroenterology and Motility
Volume23
Issue number2
DOIs
StatePublished - 1 Jan 2017
Externally publishedYes

Keywords

  • Intestinal obstruction
  • Intestinal pseudo-obstruction
  • Manometry
  • Myoelectric complex
  • Small intestine

Fingerprint

Dive into the research topics of 'Chronic intestinal pseudo-obstruction: Clinical and manometric characteristics in the Chilean population'. Together they form a unique fingerprint.

Cite this