TY - JOUR
T1 - Circadian and sleep-deprivation variations of monophosphorylated MAP-Kinase in hypothalamus and pons of rats
AU - Mijangos-Moreno, Stephanie
AU - Poot-Aké, Alwin
AU - Sarro-Ramírez, Andrea
AU - Jiménez-Moreno, Ramsés
AU - Pacheco-Pantoja, Elda
AU - Aquino-Hernández, Pedro
AU - Salas-Crisóstomo, Mireille
AU - Arias-Carrión, Oscar
AU - Murillo-Rodríguez, Eric
N1 - Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2015/9/3
Y1 - 2015/9/3
N2 - Behavior and physiological changes are under the influence of circadian and homeostatic variations. Temporal alignment regulates timing of neurobiological phenomena, such as protein phosphorylation. In the current report, we describe the circadian and sleep homeostatic phosphorylated mitogen-activated protein kinase (MAP-K) variations in hypothalamus and pons of rats across 24 h as well as after sleep deprivation. In the circadian study, MAP-K expression showed a building-up profile during the dark phase in hypothalamus, whereas an increase across the lights-on period was found in pons. On the other hand, that phosphorylation of MAP-K in hypothalamus and pons displayed a significant reduction after sleep rebound period. Data demonstrate that MAP-K phosphorylation undergoes circadian and sleep homeostatic variations in brain areas linked to sleep modulation.
AB - Behavior and physiological changes are under the influence of circadian and homeostatic variations. Temporal alignment regulates timing of neurobiological phenomena, such as protein phosphorylation. In the current report, we describe the circadian and sleep homeostatic phosphorylated mitogen-activated protein kinase (MAP-K) variations in hypothalamus and pons of rats across 24 h as well as after sleep deprivation. In the circadian study, MAP-K expression showed a building-up profile during the dark phase in hypothalamus, whereas an increase across the lights-on period was found in pons. On the other hand, that phosphorylation of MAP-K in hypothalamus and pons displayed a significant reduction after sleep rebound period. Data demonstrate that MAP-K phosphorylation undergoes circadian and sleep homeostatic variations in brain areas linked to sleep modulation.
KW - hypothalamus
KW - mitogen-activated protein kinase
KW - pons
KW - sleep deprivation
KW - Western blot
UR - http://www.scopus.com/inward/record.url?scp=84931830394&partnerID=8YFLogxK
U2 - 10.1080/09291016.2015.1052651
DO - 10.1080/09291016.2015.1052651
M3 - Artículo
AN - SCOPUS:84931830394
SN - 0929-1016
VL - 46
SP - 763
EP - 770
JO - Biological Rhythm Research
JF - Biological Rhythm Research
IS - 5
ER -