Congenital toxoplasmosis: Specific IgG subclasses in mother/newborn pairs

Irma Canedo-Solares, María De La Luz Galván-Ramírez, Héctor Luna-Pastén, Laura Rocío Rodríguez Pérez, Luz Belinda Ortiz-Alegría, Claudia Patricia Rico-Torres, Marcela Vela-Amieva, Martha Pérez-Andrade, Ricardo Figueroa-DamiÁn, Dolores Correa

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Anti-Toxoplasma gondii antibodies of all IgG subclasses were studied in mother/newborn pairs. IgG1 in the mothers and IgG3 in the newborns were related to offspring clinical problems; IgG2 and IgG3 in the babies were markers of vertical transmission, and IgG4 in mothers or children were associated to clinical problems. IgG subclasses may be markers of congenital infection or clinical outcome.

Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalPediatric Infectious Disease Journal
Volume27
Issue number5
DOIs
StatePublished - 1 Jan 2008
Externally publishedYes

Keywords

  • Antibodies
  • congenital toxoplasmosis
  • fetal response
  • IgG subclasses
  • placenta

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