TY - JOUR
T1 - Cortistatin modulates memory processes in rats
AU - Sánchez-Alavez, Manuel
AU - Gómez-Chavarín, Margarita
AU - Navarro, Luz
AU - Jiménez-Anguiano, Anabel
AU - Murillo-Rodríguez, Eric
AU - Prado-Alcalá, Roberto A.
AU - Drucker-Colin, Rene
AU - Prospéro-García, Oscar
PY - 2000/3/2
Y1 - 2000/3/2
N2 - Cortistatin (CST) is a recently described neuropeptide with high structural homology with somatostatin. Its mRNA is restricted to gamma amino butyric acid (GABA)-containing cells in the cerebral cortex and hippocampus. CST modulates the electrophysiology of the hippocampus and cerebral cortex of rats; hence, it may be modulating mnemonic processes. In this study, we have evaluated the effect of CST and somatostatin (SS) on short- and long-term memory (STM and LTM, respectively), as well as on the extinction of the behavior by using the footshock passive avoidance behavioral test. In addition, we tested the ability of both neuropeptides to affect the generation of cAMP in hippocampal neurons in culture. Results showed that the administration of either CST or SS into the hippocampal CA1 deteriorates memory consolidation in a dose-response fashion and facilitates the extinction of the learned behavior. CST was more potent than SS. Likewise, CST increases cAMP while SS decreases it. These results strongly support a modulatory role for CST in memory processes. Copyright (C) 2000 Elsevier Science B.V.
AB - Cortistatin (CST) is a recently described neuropeptide with high structural homology with somatostatin. Its mRNA is restricted to gamma amino butyric acid (GABA)-containing cells in the cerebral cortex and hippocampus. CST modulates the electrophysiology of the hippocampus and cerebral cortex of rats; hence, it may be modulating mnemonic processes. In this study, we have evaluated the effect of CST and somatostatin (SS) on short- and long-term memory (STM and LTM, respectively), as well as on the extinction of the behavior by using the footshock passive avoidance behavioral test. In addition, we tested the ability of both neuropeptides to affect the generation of cAMP in hippocampal neurons in culture. Results showed that the administration of either CST or SS into the hippocampal CA1 deteriorates memory consolidation in a dose-response fashion and facilitates the extinction of the learned behavior. CST was more potent than SS. Likewise, CST increases cAMP while SS decreases it. These results strongly support a modulatory role for CST in memory processes. Copyright (C) 2000 Elsevier Science B.V.
KW - cAMP
KW - Long-term memory
KW - Memory extinction
KW - Passive avoidance test
KW - Short-term memory
KW - Somatostatin
UR - http://www.scopus.com/inward/record.url?scp=0033970109&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(99)02336-7
DO - 10.1016/S0006-8993(99)02336-7
M3 - Artículo
C2 - 10700600
AN - SCOPUS:0033970109
SN - 0006-8993
VL - 858
SP - 78
EP - 83
JO - Brain Research
JF - Brain Research
IS - 1
ER -