TY - JOUR
T1 - Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats
AU - Diaz-Ruiz, Araceli
AU - Rios, Camilo
AU - Duarte, Ivonne
AU - Correa, Dolores
AU - Guizar-Sahagun, Gabriel
AU - Grijalva, Israel
AU - Ibarra, Antonio
PY - 1999/4/30
Y1 - 1999/4/30
N2 - Besides its immunosuppressive/anti-inflammatory activity, cyclosporin-A (CsA) may protect damaged tissues from lipid peroxidation (LP) by free radicals. To determine the effect of CsA on LP spinal cord (SC) injury, Wistar rats were treated with either vehicle or CsA (2.5 mg/kg per 12 h i.p.) 1, 2, 6 or 12 h after SC trauma by T8-T9 spinal cord contusion, analyzing LP 24 h after injury at the lesion site by the lipid fluorescent products formation method. CsA significantly diminished LP to levels below control values after contusion (P < 0.05). The greater inhibition was observed when CsA was given during the first 6 h after injury, furthermore, animals showed a significant clinical improvement. Results show that CsA may be beneficial to injured tissue by inhibiting the levels of LP.
AB - Besides its immunosuppressive/anti-inflammatory activity, cyclosporin-A (CsA) may protect damaged tissues from lipid peroxidation (LP) by free radicals. To determine the effect of CsA on LP spinal cord (SC) injury, Wistar rats were treated with either vehicle or CsA (2.5 mg/kg per 12 h i.p.) 1, 2, 6 or 12 h after SC trauma by T8-T9 spinal cord contusion, analyzing LP 24 h after injury at the lesion site by the lipid fluorescent products formation method. CsA significantly diminished LP to levels below control values after contusion (P < 0.05). The greater inhibition was observed when CsA was given during the first 6 h after injury, furthermore, animals showed a significant clinical improvement. Results show that CsA may be beneficial to injured tissue by inhibiting the levels of LP.
KW - Cyclosporin-A
KW - Free-radicals
KW - Inflammatory response
KW - Lipid peroxidation
KW - Neuroprotection
KW - Spinal cord injury
UR - http://www.scopus.com/inward/record.url?scp=0345711646&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(99)00255-4
DO - 10.1016/S0304-3940(99)00255-4
M3 - Artículo
C2 - 10336184
AN - SCOPUS:0345711646
SN - 0304-3940
VL - 266
SP - 61
EP - 64
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -