Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats

Araceli Diaz-Ruiz, Camilo Rios, Ivonne Duarte, Dolores Correa, Gabriel Guizar-Sahagun, Israel Grijalva, Antonio Ibarra

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Besides its immunosuppressive/anti-inflammatory activity, cyclosporin-A (CsA) may protect damaged tissues from lipid peroxidation (LP) by free radicals. To determine the effect of CsA on LP spinal cord (SC) injury, Wistar rats were treated with either vehicle or CsA (2.5 mg/kg per 12 h i.p.) 1, 2, 6 or 12 h after SC trauma by T8-T9 spinal cord contusion, analyzing LP 24 h after injury at the lesion site by the lipid fluorescent products formation method. CsA significantly diminished LP to levels below control values after contusion (P < 0.05). The greater inhibition was observed when CsA was given during the first 6 h after injury, furthermore, animals showed a significant clinical improvement. Results show that CsA may be beneficial to injured tissue by inhibiting the levels of LP.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalNeuroscience Letters
Volume266
Issue number1
DOIs
StatePublished - 30 Apr 1999
Externally publishedYes

Keywords

  • Cyclosporin-A
  • Free-radicals
  • Inflammatory response
  • Lipid peroxidation
  • Neuroprotection
  • Spinal cord injury

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