TY - JOUR
T1 - Detrimental role of prolonged sleep deprivation on adult neurogenesis
AU - Fernandes, Carina
AU - Rocha, Nuno Barbosa F.
AU - Rocha, Susana
AU - Herrera-Solís, Andrea
AU - Salas-Pacheco, José
AU - García-García, Fabio
AU - Murillo-Rodríguez, Eric
AU - Yuan, Ti Fei
AU - Machado, Sergio
AU - Arias-Carrión, Oscar
N1 - Publisher Copyright:
© 2015 Fernandes, Rocha, Rocha, Herrera-Solís, Salas-Pacheco, GarcíaGarcía, Murillo-Rodríguez, Yuan, Machado and Arias-Carrión.
PY - 2015/4/14
Y1 - 2015/4/14
N2 - Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.
AB - Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.
KW - Adult neurogenesis
KW - Antidepressants
KW - Circadian rhythms
KW - Hippocampus
KW - Hypnotic drugs
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=84927610564&partnerID=8YFLogxK
U2 - 10.3389/fncel.2015.00140
DO - 10.3389/fncel.2015.00140
M3 - Artículo
AN - SCOPUS:84927610564
SN - 1662-5102
VL - 9
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
IS - APR
M1 - A140
ER -