Detrimental role of prolonged sleep deprivation on adult neurogenesis

Carina Fernandes, Nuno Barbosa F. Rocha, Susana Rocha, Andrea Herrera-Solís, José Salas-Pacheco, Fabio García-García, Eric Murillo-Rodríguez, Ti Fei Yuan, Sergio Machado, Oscar Arias-Carrión

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.

Original languageEnglish
Article numberA140
JournalFrontiers in Cellular Neuroscience
Volume9
Issue numberAPR
DOIs
StatePublished - 14 Apr 2015

Keywords

  • Adult neurogenesis
  • Antidepressants
  • Circadian rhythms
  • Hippocampus
  • Hypnotic drugs
  • Sleep

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