Human T and B cell epitope mapping of Taenia solium paramyosin

José Vázquez-Talavera, Carlos F. Solís, Edith Medina-Escutia, Zoila Morales López, Jefferson Proaño, Dolores Correa, Juan Pedro Laclette

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20 Scopus citations

Abstract

Taenia solium paramyosin is an immunodominant antigen in human and porcine cysticercosis that has shown promise as a vaccine candidate against schistosomiasis and some filariasis. There are few studies to identify the immunologically relevant regions of paramyosin. In this work, we characterize the humoral and cellular response of neuro-cysticercotic patients against T. solium paramyosin. Western blots using different recombinant fragments of T. solium paramyosin, showed that the sera from neurocysticercotic patients were strongly reactive against the carboxyl end region, with poor recognition of the central and amino regions. In contrast, the cellular immune response of patients did not show preferential recognition of any region of paramyosin.

Original languageEnglish
Pages (from-to)575-579
Number of pages5
JournalParasite Immunology
Volume23
Issue number11
DOIs
StatePublished - 1 Dec 2001
Externally publishedYes

Keywords

  • Cysticercosis
  • Epitope mapping
  • Paramyosin
  • Taenia solium

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