TY - JOUR
T1 - Immunization with neural-derived peptides as a neuroprotective therapy for spinal cord injury
AU - Ibarra-García, Andrea Paola
AU - Ibarra, Antonio
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Spinal cord injury (SCI) induces several destructive events that develop immediately after the primary insult. These phenomena increase tissue damage; that is why, numerous therapeutic approaches are studied in order to neutralize these destructive mechanisms. In line with this, several studies indicate that after injury, neural tissue could be protected by an adaptive immune response directed against self-antigens. Immunization with neural-derived peptides (INDP) reduces secondary degeneration of neurons after spinal cord insult and promotes a significant motor recovery. The combination of antioxidants or other immunomodulatory peptides after SCI can improve the protective effect induced by INDP. INDP in acute SCI is a promising strategy, so further studies should be addressed to be able to formulate the best strategy.
AB - Spinal cord injury (SCI) induces several destructive events that develop immediately after the primary insult. These phenomena increase tissue damage; that is why, numerous therapeutic approaches are studied in order to neutralize these destructive mechanisms. In line with this, several studies indicate that after injury, neural tissue could be protected by an adaptive immune response directed against self-antigens. Immunization with neural-derived peptides (INDP) reduces secondary degeneration of neurons after spinal cord insult and promotes a significant motor recovery. The combination of antioxidants or other immunomodulatory peptides after SCI can improve the protective effect induced by INDP. INDP in acute SCI is a promising strategy, so further studies should be addressed to be able to formulate the best strategy.
KW - A91
KW - immunization
KW - paraplegia
KW - protective autoimmunity
UR - http://www.scopus.com/inward/record.url?scp=85207903064&partnerID=8YFLogxK
U2 - 10.37349/ent.2021.00009
DO - 10.37349/ent.2021.00009
M3 - Artículo de revisión
AN - SCOPUS:85207903064
SN - 2769-6510
VL - 1
SP - 111
EP - 120
JO - Exploration of Neuroprotective Therapy
JF - Exploration of Neuroprotective Therapy
IS - 2
ER -