TY - JOUR
T1 - Immunization with neural-derived peptides increases neurogenesis in rats with chronic spinal cord injury
AU - Rodríguez-Barrera, Roxana
AU - Flores-Romero, Adrián
AU - García, Elisa
AU - Fernández-Presas, Ana Maria
AU - Incontri-Abraham, Diego
AU - Navarro-Torres, Lisset
AU - García-Sánchez, Julián
AU - Juárez-Vignon Whaley, Juan José
AU - Madrazo, Ignacio
AU - Ibarra, Antonio
N1 - Publisher Copyright:
© 2020 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Aims: Immunization with neural-derived peptides (INDP) has demonstrated to be a promising therapy to achieve a regenerative effect in the chronic phase of the spinal cord injury (SCI). Nevertheless, INDP-induced neurogenic effects in the chronic stage of SCI have not been explored. Methods and Results: In this study, we analyzed the effect of INDP on both motor and sensitive function recovery; afterward, we assessed neurogenesis and determined the production of cytokines (IL-4, IL-10, and TNF alpha) and neurotrophic factors (BDNF and GAP-43). During the chronic stage of SCI, rats subjected to INDP showed a significant increase in both motor and sensitive recovery when compared to the control group. Moreover, we found a significant increase in neurogenesis, mainly at the central canal and at both the dorsal and ventral horns of INDP-treated animals. Finally, INDP induced significant production of antiinflammatory and regeneration-associated proteins in the chronic stages of SCI. Conclusions: These findings suggest that INDP has a neurogenic effect that could improve motor and sensitive recovery in the chronic stage of SCI. Moreover, our results also envision the use of INDP as a possible therapeutic strategy for other trauma-related disorders like traumatic brain injury.
AB - Aims: Immunization with neural-derived peptides (INDP) has demonstrated to be a promising therapy to achieve a regenerative effect in the chronic phase of the spinal cord injury (SCI). Nevertheless, INDP-induced neurogenic effects in the chronic stage of SCI have not been explored. Methods and Results: In this study, we analyzed the effect of INDP on both motor and sensitive function recovery; afterward, we assessed neurogenesis and determined the production of cytokines (IL-4, IL-10, and TNF alpha) and neurotrophic factors (BDNF and GAP-43). During the chronic stage of SCI, rats subjected to INDP showed a significant increase in both motor and sensitive recovery when compared to the control group. Moreover, we found a significant increase in neurogenesis, mainly at the central canal and at both the dorsal and ventral horns of INDP-treated animals. Finally, INDP induced significant production of antiinflammatory and regeneration-associated proteins in the chronic stages of SCI. Conclusions: These findings suggest that INDP has a neurogenic effect that could improve motor and sensitive recovery in the chronic stage of SCI. Moreover, our results also envision the use of INDP as a possible therapeutic strategy for other trauma-related disorders like traumatic brain injury.
KW - A91 peptide
KW - chronic stage
KW - INDP
KW - motor recovery
KW - neurogenesis
KW - paraplegia
KW - protective autoimmunity
KW - protective autoimmunity
KW - SCI
KW - sensitive recovery
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85084200491&partnerID=8YFLogxK
U2 - 10.1111/cns.13368
DO - 10.1111/cns.13368
M3 - Artículo
C2 - 32352656
AN - SCOPUS:85084200491
SN - 1755-5930
VL - 26
SP - 650
EP - 658
JO - CNS Neuroscience and Therapeutics
JF - CNS Neuroscience and Therapeutics
IS - 6
ER -