TY - JOUR
T1 - Increased resting state triple network functional connectivity in undergraduate problematic cannabis users
T2 - A preliminary eeg coherence study
AU - Imperatori, Claudio
AU - Massullo, Chiara
AU - Carbone, Giuseppe Alessio
AU - Panno, Angelo
AU - Giacchini, Marta
AU - Capriotti, Cristina
AU - Lucarini, Elisa
AU - Zampa, Benedetta Ramella
AU - Murillo-rodríguez, Eric
AU - Machado, Sérgio
AU - Farina, Benedetto
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addictive disorders. In the current research, we have investigated the association between problematic cannabis use (PCU) and triple-network electroencephalographic (EEG) functional connectivity. Twelve participants with PCU and 24 non-PCU participants were included in the study. EEG recordings were performed during resting state (RS). The exact Low-Resolution Electromagnetic Tomography software (eLORETA) was used for all EEG analyses. Compared to non-PCU, PCU participants showed an increased delta connectivity between the salience network (SN) and central executive network (CEN), specifically, between the dorsal anterior cingulate cortex and right posterior parietal cortex. The strength of delta connectivity between the SN and CEN was positively and significantly correlated with higher problematic patterns of cannabis use after controlling for age, sex, educational level, tobacco use, problematic alcohol use, and general psychopathology (rp = 0.40, p = 0.030). Taken together, our results show that individuals with PCU could be characterized by a specific dysfunctional interaction between the SN and CEN during RS, which might reflect the neurophysiological underpinnings of attentional and emotional processes of cannabis-related thoughts, memories, and craving.
AB - An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addictive disorders. In the current research, we have investigated the association between problematic cannabis use (PCU) and triple-network electroencephalographic (EEG) functional connectivity. Twelve participants with PCU and 24 non-PCU participants were included in the study. EEG recordings were performed during resting state (RS). The exact Low-Resolution Electromagnetic Tomography software (eLORETA) was used for all EEG analyses. Compared to non-PCU, PCU participants showed an increased delta connectivity between the salience network (SN) and central executive network (CEN), specifically, between the dorsal anterior cingulate cortex and right posterior parietal cortex. The strength of delta connectivity between the SN and CEN was positively and significantly correlated with higher problematic patterns of cannabis use after controlling for age, sex, educational level, tobacco use, problematic alcohol use, and general psychopathology (rp = 0.40, p = 0.030). Taken together, our results show that individuals with PCU could be characterized by a specific dysfunctional interaction between the SN and CEN during RS, which might reflect the neurophysiological underpinnings of attentional and emotional processes of cannabis-related thoughts, memories, and craving.
KW - EEG functional connectivity
KW - ELORETA
KW - Problematic cannabis use
KW - Resting state
KW - Triple network
UR - http://www.scopus.com/inward/record.url?scp=85081000441&partnerID=8YFLogxK
U2 - 10.3390/brainsci10030136
DO - 10.3390/brainsci10030136
M3 - Artículo
AN - SCOPUS:85081000441
SN - 2076-3425
VL - 10
JO - Brain Sciences
JF - Brain Sciences
IS - 3
M1 - 136
ER -