TY - JOUR
T1 - Intrahypothalamic administration of modafinil increases expression of MAP-kinase in hypothalamus and pons in rats
AU - Poot-Aké, Alwin
AU - Mijangos-Moreno, Stephanie
AU - Manjarrez-Martin, Danielle
AU - Jiménez-Moreno, Ramsés
AU - Aquino-Hernández, Pedro R.
AU - Pacheco-Pantoja, Elda
AU - Arias-Carrión, Oscar
AU - Sarro-Ramírez, Andrea
AU - Arankowsky-Sandoval, Gloria
AU - Murillo-Rodríguez, Eric
N1 - Publisher Copyright:
© 2015 Bentham Science Publishers.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Modafinil (MOD) it has to be considered as a wake-inducing drug to treat sleep disorders such as excessive sleepiness in narcolepsy, shift-work disorder, and obstructive/sleep apnea syndrome. Current evidence suggests that MOD induces waking involving the dopamine D1 receptor. However, little is known regarding the molecular elements linked in the wake-promoting actions of MOD. Since the D1 receptor activates the mitogen-activated protein kinase (MAP-K) cascade, it raises the interesting possibility that effects of MOD would depend upon the activation of MAP-K. Here we tested the expression of MAP-K in hypothalamus as well as pons after the microinjection of MOD (10 or 20μg/1μL) in rats into anterior hypothalamus, a wake-inducing brain area. Intrahypothalamic injections of MOD promoted MAP-K phosphorylation in hypothalamus and pons. Taken together, these results suggest that the wake-inducing compound MOD promotes the MAP-K phosphorylation.
AB - Modafinil (MOD) it has to be considered as a wake-inducing drug to treat sleep disorders such as excessive sleepiness in narcolepsy, shift-work disorder, and obstructive/sleep apnea syndrome. Current evidence suggests that MOD induces waking involving the dopamine D1 receptor. However, little is known regarding the molecular elements linked in the wake-promoting actions of MOD. Since the D1 receptor activates the mitogen-activated protein kinase (MAP-K) cascade, it raises the interesting possibility that effects of MOD would depend upon the activation of MAP-K. Here we tested the expression of MAP-K in hypothalamus as well as pons after the microinjection of MOD (10 or 20μg/1μL) in rats into anterior hypothalamus, a wake-inducing brain area. Intrahypothalamic injections of MOD promoted MAP-K phosphorylation in hypothalamus and pons. Taken together, these results suggest that the wake-inducing compound MOD promotes the MAP-K phosphorylation.
KW - Dopamine
KW - Hypothalamus
KW - Modafinil
KW - Narcolepsy
KW - Pons
KW - Protein
KW - Rat
KW - Wakefulness
KW - Western blot
UR - http://www.scopus.com/inward/record.url?scp=84929617221&partnerID=8YFLogxK
U2 - 10.2174/1871527314666150429113609
DO - 10.2174/1871527314666150429113609
M3 - Artículo
C2 - 25921741
AN - SCOPUS:84929617221
SN - 1871-5273
VL - 14
SP - 463
EP - 467
JO - CNS and Neurological Disorders - Drug Targets
JF - CNS and Neurological Disorders - Drug Targets
IS - 4
ER -