TY - JOUR
T1 - MCP-1, RANTES, and SDF-1 polymorphisms in Mexican patients with systemic lupus erythematosus
AU - Lima, Guadalupe
AU - Soto-Vega, Elena
AU - Atisha-Fregoso, Yemil
AU - Sánchez-Guerrero, Jorge
AU - Vallejo, Maite
AU - Vargas-Alarcón, Gilberto
AU - Llorente, Luis
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Chemokines and cytokines play an important role in the inflammatory development and progression of autoimmune diseases. The aim of the present study was to evaluate the role of MCP-1, SDF-1, and RANTES polymorphisms as susceptibility markers for systemic lupus erythematosus (SLE) in a group of Mexican patients. MCP-1-2518, SDF-1 G801A, and RANTES-28 polymorphisms were determined in 242 patients with SLE and 220 ethnically matched healthy controls by the polymerase chain reaction-restriction fragment length polymorphism technique. The differences between patients and healthy controls were evaluated by χ2, Fisher's exact test, and Woolf method for odds ratio. A moderately increased frequency of MCP-1-2518 A allele (p = 0.033, pC = NS) and AA genotype (p = 0.017, pC = NS) existed in SLE patients compared with healthy controls. There was a relationship between polymorphisms and some clinical and laboratory characteristics. SLE patients with and without antiphospholipid syndrome demonstrated different distribution of SDF-1 G801A genotype frequencies. On the other hand, patients with leukopenia, anti-dsDNA, and antiphospholipid autoantibodies demonstrated different MCP-1-2518 genotype distribution compared with patients without these features. Our results suggest that MCP-1 polymorphism is moderately associated with the genetic susceptibility to SLE in Mexican individuals. The polymorphisms could be related to specific clinical and laboratory characteristics in these patients.
AB - Chemokines and cytokines play an important role in the inflammatory development and progression of autoimmune diseases. The aim of the present study was to evaluate the role of MCP-1, SDF-1, and RANTES polymorphisms as susceptibility markers for systemic lupus erythematosus (SLE) in a group of Mexican patients. MCP-1-2518, SDF-1 G801A, and RANTES-28 polymorphisms were determined in 242 patients with SLE and 220 ethnically matched healthy controls by the polymerase chain reaction-restriction fragment length polymorphism technique. The differences between patients and healthy controls were evaluated by χ2, Fisher's exact test, and Woolf method for odds ratio. A moderately increased frequency of MCP-1-2518 A allele (p = 0.033, pC = NS) and AA genotype (p = 0.017, pC = NS) existed in SLE patients compared with healthy controls. There was a relationship between polymorphisms and some clinical and laboratory characteristics. SLE patients with and without antiphospholipid syndrome demonstrated different distribution of SDF-1 G801A genotype frequencies. On the other hand, patients with leukopenia, anti-dsDNA, and antiphospholipid autoantibodies demonstrated different MCP-1-2518 genotype distribution compared with patients without these features. Our results suggest that MCP-1 polymorphism is moderately associated with the genetic susceptibility to SLE in Mexican individuals. The polymorphisms could be related to specific clinical and laboratory characteristics in these patients.
KW - Chemokines
KW - Monocyte chemoattractant protein 1
KW - Polymorphisms
KW - Regulated on activation normal T cell expressed and secreted
KW - Stromal cell-derived factor-1
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=37849044527&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2007.10.007
DO - 10.1016/j.humimm.2007.10.007
M3 - Artículo
C2 - 18191726
AN - SCOPUS:37849044527
SN - 0198-8859
VL - 68
SP - 980
EP - 985
JO - Human Immunology
JF - Human Immunology
IS - 12
ER -