Microvascular dysfunction after spinal cord injury

Humberto Mestre, Antonio Ibarra

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Acute traumatic spinal cord injury (SCI) is a growing concern for clinical practice. The vast etiologies of SCI make this pathology difficult to diagnose in an effective and timely manner. Advances in technology and in our understanding of SCI have improved our ability to detect patients who have sustained an injury of this type; however, our knowledge is limited and these patients, in spite of intervention, are left with permanent disabilities. The predominant age group affected by SCI clusters around young productive males, which severely affects the financial, psychological, and social aspects of their lives. Our inability to treat SCI lies in the complex pathophysiology of this disease. This chapter aims at describing the hallmarks of microvasculature dysfunction after SCI, emphasizing the modifications suffered by the endothelial cells of the blood-spinal cord barrier (BSCB). An effort has also been made to address the therapeutic interventions directed towards these vascular mechanisms and the clinical implications of these processes.

Original languageEnglish
Title of host publicationEndothelial Cell Plasticity in the Normal and Injured Central Nervous System
PublisherCRC Press
Pages153-174
Number of pages22
ISBN (Electronic)9781466599239
ISBN (Print)9781466599215
DOIs
StatePublished - 1 Jan 2015

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