Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats

Eric Murillo-Rodríguez; Reyes Haro; Marcela Palomero-Rivero; Diana Millán-Aldaco; René Drucker-Colín

doi:10.1016/j.bbr.2006.10.016

Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats

Eric Murillo-Rodríguez, Reyes Haro, Marcela Palomero-Rivero, Diana Millán-Aldaco, René Drucker-Colín

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82 Scopus citations

Abstract

Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10 μg/5 μl) the extracellular levels of dopamine (DA) and l-DOPA collected from the nucleus accumbens were increased and decreased, respectively. Separately, the icv administration of MOD (10 μg/5 μl) to rats enhanced wakefulness (W) whereas diminished sleep during 4 h. Lastly, the alertness induced by MOD was partially antagonized by the sleep-inducing endocannabinoid anandamide (ANA). We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA.

Original language	English
Pages (from-to)	353-357
Number of pages	5
Journal	Behavioural Brain Research
Volume	176
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2006.10.016
State	Published - 25 Jan 2007
Externally published	Yes

Keywords

Dopamine
Endocannabinoid
Microdialysis
Modafinil
Sleep
Waking

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10.1016/j.bbr.2006.10.016

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title = "Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats",

abstract = "Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10 μg/5 μl) the extracellular levels of dopamine (DA) and l-DOPA collected from the nucleus accumbens were increased and decreased, respectively. Separately, the icv administration of MOD (10 μg/5 μl) to rats enhanced wakefulness (W) whereas diminished sleep during 4 h. Lastly, the alertness induced by MOD was partially antagonized by the sleep-inducing endocannabinoid anandamide (ANA). We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA.",

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T1 - Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats

AU - Murillo-Rodríguez, Eric

AU - Haro, Reyes

AU - Palomero-Rivero, Marcela

AU - Millán-Aldaco, Diana

AU - Drucker-Colín, René

PY - 2007/1/25

Y1 - 2007/1/25

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AB - Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10 μg/5 μl) the extracellular levels of dopamine (DA) and l-DOPA collected from the nucleus accumbens were increased and decreased, respectively. Separately, the icv administration of MOD (10 μg/5 μl) to rats enhanced wakefulness (W) whereas diminished sleep during 4 h. Lastly, the alertness induced by MOD was partially antagonized by the sleep-inducing endocannabinoid anandamide (ANA). We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA.

KW - Dopamine

KW - Endocannabinoid

KW - Microdialysis

KW - Modafinil

KW - Sleep

KW - Waking

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Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats

Abstract

Keywords

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