TY - CHAP
T1 - Modulation of the microbiota-gut-brain axis by bioactive food, prebiotics, and probiotics decelerates the course of Alzheimer's disease
AU - Cuervo-Zanatta, Daniel
AU - Perez-Grijalva, Brenda
AU - González-Magaña, Esael
AU - Hernadez-Acosta, Julieta
AU - Murugesan, Selvasankar
AU - García-Mena, Jaime
AU - Perez-Cruz, Claudia
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - It is evident that nowadays, the percentage of aged population is constantly increasing worldwide in the developed and nondeveloped countries. In addition, there is more evidence that aging is the main risk factor to develop Alzheimer ´s disease (AD), a neurodegenerative condition that impairs memory and cognitive performance. Among the principal pathological hallmarks for AD, are protein aggregation in the brain, which are associated with inflammation and neuronal dysfunction and currently, there are no disease-modifying drugs to prevent or cure AD. However, recent studies have explored the impact of the Mediterranean diet and bioactive food to prevent or delay the onset of dementia. Bioactive food ingestion has strong antioxidant and antiinflammatory effects, and notably, bioactive food also modulates gut microbiota (GM) composition. GM is altered in AD, and patients show a dominant proinflammatory profile compared to age-matched control subjects. It is known that ingestion of bioactive food, prebiotics, or probiotics modulates GM composition and improves cognitive scores in predemented and demented subjects. This review aims to outline the mechanism of action of bioactive food, prebiotics, and probiotics in the prevention of dementia through the modulation of the microbiota-gut-brain axis. We provide documented evidence that bioactive food, an accessible diet with minimal side effects, can decelerate the rate of neurodegeneration in the aging population.
AB - It is evident that nowadays, the percentage of aged population is constantly increasing worldwide in the developed and nondeveloped countries. In addition, there is more evidence that aging is the main risk factor to develop Alzheimer ´s disease (AD), a neurodegenerative condition that impairs memory and cognitive performance. Among the principal pathological hallmarks for AD, are protein aggregation in the brain, which are associated with inflammation and neuronal dysfunction and currently, there are no disease-modifying drugs to prevent or cure AD. However, recent studies have explored the impact of the Mediterranean diet and bioactive food to prevent or delay the onset of dementia. Bioactive food ingestion has strong antioxidant and antiinflammatory effects, and notably, bioactive food also modulates gut microbiota (GM) composition. GM is altered in AD, and patients show a dominant proinflammatory profile compared to age-matched control subjects. It is known that ingestion of bioactive food, prebiotics, or probiotics modulates GM composition and improves cognitive scores in predemented and demented subjects. This review aims to outline the mechanism of action of bioactive food, prebiotics, and probiotics in the prevention of dementia through the modulation of the microbiota-gut-brain axis. We provide documented evidence that bioactive food, an accessible diet with minimal side effects, can decelerate the rate of neurodegeneration in the aging population.
KW - Fecal microbiota
KW - Gut-brain axis
KW - Inflammation
KW - Neurodegeneration
KW - Short-chain fatty acids
KW - Transgenic mice
UR - http://www.scopus.com/inward/record.url?scp=85110623049&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-819489-8.00019-3
DO - 10.1016/B978-0-12-819489-8.00019-3
M3 - Capítulo
AN - SCOPUS:85110623049
T3 - Studies in Natural Products Chemistry
SP - 51
EP - 86
BT - Studies in Natural Products Chemistry
PB - Elsevier B.V.
ER -