TY - JOUR
T1 - NF-κB and Its Regulators During Pregnancy
AU - Gómez-Chávez, Fernando
AU - Correa, Dolores
AU - Navarrete-Meneses, Pilar
AU - Cancino-Diaz, Juan Carlos
AU - Cancino-Diaz, Mario Eugenio
AU - Rodríguez-Martínez, Sandra
N1 - Publisher Copyright:
© Copyright © 2021 Gómez-Chávez, Correa, Navarrete-Meneses, Cancino-Diaz, Cancino-Diaz and Rodríguez-Martínez.
PY - 2021/5/5
Y1 - 2021/5/5
N2 - The transcriptional factor NF-κB is a nuclear factor involved in both physiological and pathological processes. This factor can control the transcription of more than 400 genes, including cytokines, chemokines, and their modulators, immune and non-immune receptors, proteins involved in antigen presentation and cell adhesion, acute phase and stress response proteins, regulators of apoptosis, growth factors, other transcription factors and their regulators, as well as different enzymes; all these molecules control several biological processes. NF-κB is a tightly regulated molecule that has also been related to apoptosis, cell proliferation, inflammation, and the control of innate and adaptive immune responses during onset of labor, in which it has a crucial role; thus, early activation of this factor may have an adverse effect, by inducing premature termination of pregnancy, with bad outcomes for the mother and the fetus, including product loss. Reviews compiling the different activities of NF-κB have been reported. However, an update regarding NF-κB regulation during pregnancy is lacking. In this work, we aimed to describe the state of the art around NF-κB activity, its regulatory role in pregnancy, and the effect of its dysregulation due to invasion by pathogens like Trichomonas vaginalis and Toxoplasma gondii as examples.
AB - The transcriptional factor NF-κB is a nuclear factor involved in both physiological and pathological processes. This factor can control the transcription of more than 400 genes, including cytokines, chemokines, and their modulators, immune and non-immune receptors, proteins involved in antigen presentation and cell adhesion, acute phase and stress response proteins, regulators of apoptosis, growth factors, other transcription factors and their regulators, as well as different enzymes; all these molecules control several biological processes. NF-κB is a tightly regulated molecule that has also been related to apoptosis, cell proliferation, inflammation, and the control of innate and adaptive immune responses during onset of labor, in which it has a crucial role; thus, early activation of this factor may have an adverse effect, by inducing premature termination of pregnancy, with bad outcomes for the mother and the fetus, including product loss. Reviews compiling the different activities of NF-κB have been reported. However, an update regarding NF-κB regulation during pregnancy is lacking. In this work, we aimed to describe the state of the art around NF-κB activity, its regulatory role in pregnancy, and the effect of its dysregulation due to invasion by pathogens like Trichomonas vaginalis and Toxoplasma gondii as examples.
KW - Bcl-3
KW - IκBNS
KW - IκBz
KW - NF-κB
KW - NF-κB regulation
KW - pregnancy
KW - reproductive system
UR - http://www.scopus.com/inward/record.url?scp=85106054923&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.679106
DO - 10.3389/fimmu.2021.679106
M3 - Artículo de revisión
C2 - 34025678
AN - SCOPUS:85106054923
SN - 1664-3224
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 679106
ER -