P-glycoprotein activity correlates with treatment response in 2 leukemia child patients

María J. Muñoz-Pérez, Stephania Casco, María D.C. Garza-González, Elena Soto-Vega

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Acute lymphoblastic leukemia is the most important childhood cancer. Multidrug resistance is an important factor of poor prognosis. We present the P-glycoprotein (P-gp) activity in 2 patients with different outcomes. Both patients had B-cell acute lymphoblastic leukemia; they were responding properly to the treatment, but one of them had an increment in the P-gp activity that correlates with an increment in the disease manifestation, the patient had to be hospitalized and developed sepsis and subsequently died. P-gp levels were correlated with disease progression. P-gp activity needs to be evaluated during treatment to assess and prevent disease relapse or the patient's death.

Original languageEnglish
Pages (from-to)e490-e494
JournalJournal of Pediatric Hematology/Oncology
Volume40
Issue number8
DOIs
StatePublished - 1 Nov 2018

Keywords

  • Acute lymphoblastic leukemia
  • Chemotherapy
  • Children
  • P-glycoprotein

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