Abstract
Acute lymphoblastic leukemia is the most important childhood cancer. Multidrug resistance is an important factor of poor prognosis. We present the P-glycoprotein (P-gp) activity in 2 patients with different outcomes. Both patients had B-cell acute lymphoblastic leukemia; they were responding properly to the treatment, but one of them had an increment in the P-gp activity that correlates with an increment in the disease manifestation, the patient had to be hospitalized and developed sepsis and subsequently died. P-gp levels were correlated with disease progression. P-gp activity needs to be evaluated during treatment to assess and prevent disease relapse or the patient's death.
Original language | English |
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Pages (from-to) | e490-e494 |
Journal | Journal of Pediatric Hematology/Oncology |
Volume | 40 |
Issue number | 8 |
DOIs | |
State | Published - 1 Nov 2018 |
Keywords
- Acute lymphoblastic leukemia
- Chemotherapy
- Children
- P-glycoprotein