TY - JOUR
T1 - Panic disorder and cardiovascular diseases
T2 - an overview
AU - Machado, Sergio
AU - Sancassiani, Federica
AU - Paes, Flavia
AU - Rocha, Nuno
AU - Murillo-Rodriguez, Eric
AU - Nardi, Antonio Egidio
N1 - Publisher Copyright:
© 2017 Institute of Psychiatry and Johns Hopkins University.
PY - 2017/9/3
Y1 - 2017/9/3
N2 - The association between panic disorder (PD) and cardiovascular diseases (CVD) has been extensively studied in recent years and, although some studies have shown anxiety disorders co-existing or increasing the risk of heart disease, no causal hypothesis has been well established. Thus, a critical review was performed of the studies that evaluated the association between PD and cardiovascular diseases; synthesizing the evidence on the mechanisms mediators that theoretically would be the responsible for the causal pathway between PD and CVD, specifically. This overview shows epidemiological studies, and discusses biological mechanisms that could link PD to CVD, such as pleiotropy, heart rate variability, unhealthy lifestyle, atherosclerosis, mental stress, and myocardial perfusion defects. This study tried to provide a comprehensive narrative synthesis of previously published information regarding PD and CVD and open new possibilities of clinical management and pathophysiological understanding. Some epidemiological studies have indicated that PD could be a risk factor for CVD, raising morbidity and mortality in PD, suggesting an association between them. These studies argue that PD pathophysiology could cause or potentiate CVD. However, there is no evidence in favour of a causal relationship between PD and CVD. Therefore, PD patients with suspicions of cardiovascular symptoms need redoubled attention.
AB - The association between panic disorder (PD) and cardiovascular diseases (CVD) has been extensively studied in recent years and, although some studies have shown anxiety disorders co-existing or increasing the risk of heart disease, no causal hypothesis has been well established. Thus, a critical review was performed of the studies that evaluated the association between PD and cardiovascular diseases; synthesizing the evidence on the mechanisms mediators that theoretically would be the responsible for the causal pathway between PD and CVD, specifically. This overview shows epidemiological studies, and discusses biological mechanisms that could link PD to CVD, such as pleiotropy, heart rate variability, unhealthy lifestyle, atherosclerosis, mental stress, and myocardial perfusion defects. This study tried to provide a comprehensive narrative synthesis of previously published information regarding PD and CVD and open new possibilities of clinical management and pathophysiological understanding. Some epidemiological studies have indicated that PD could be a risk factor for CVD, raising morbidity and mortality in PD, suggesting an association between them. These studies argue that PD pathophysiology could cause or potentiate CVD. However, there is no evidence in favour of a causal relationship between PD and CVD. Therefore, PD patients with suspicions of cardiovascular symptoms need redoubled attention.
KW - cardiovascular disease
KW - heart rate variability
KW - Panic disorder
KW - pleiotropy
KW - unhealthy lifestyle and atherosclerosis
UR - http://www.scopus.com/inward/record.url?scp=85029640325&partnerID=8YFLogxK
U2 - 10.1080/09540261.2017.1357540
DO - 10.1080/09540261.2017.1357540
M3 - Artículo de revisión
C2 - 28893114
AN - SCOPUS:85029640325
SN - 0954-0261
VL - 29
SP - 436
EP - 444
JO - International Review of Psychiatry
JF - International Review of Psychiatry
IS - 5
ER -