Relationship between brain-derived neurotrofic factor (Bdnf) and sleep on depression: A critical review

Bárbara C. Monteiro; Suzana Monteiro; Maristela Candida; Nathalia Adler; Flavia Paes; Nuno Rocha; Antonio Egidio Nardi; Eric Murillo-Rodriguez; Sergio Machado

doi:10.2174/1745017901713010213

Relationship between brain-derived neurotrofic factor (Bdnf) and sleep on depression: A critical review

Bárbara C. Monteiro, Suzana Monteiro, Maristela Candida, Nathalia Adler, Flavia Paes, Nuno Rocha, Antonio Egidio Nardi, Eric Murillo-Rodriguez, Sergio Machado

Anahuac Mayab University

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

The Brain-Derived Neurotrofic Factor (BDNF) is one of the most important neurotrophins in the brain and it is suggested influences the activity of the serotonergic, noradrenergic and dopaminergic pathways. In the last few years, it has been hypothesized that BDNF level is related with depression and sleep. Several studies show that depressive subjects present low levels of BDNF in the brain. Poor sleep quality is also related with alterations in the BDNF concentration. Some authors argue that most of the cases show that impaired sleep quality increases the stress and, consequently, the vulnerability to depressive disorders, suggesting that there is a relationship between sleep, depression and BDNF levels.

Original language	English
Pages (from-to)	213-219
Number of pages	7
Journal	Clinical Practice and Epidemiology in Mental Health
Volume	13
DOIs	https://doi.org/10.2174/1745017901713010213
State	Published - 1 Nov 2017

Keywords

Antidepressants
Bdnf
Bdnf studies
Depression
Sleep
Sleep quality

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title = "Relationship between brain-derived neurotrofic factor (Bdnf) and sleep on depression: A critical review",

abstract = "The Brain-Derived Neurotrofic Factor (BDNF) is one of the most important neurotrophins in the brain and it is suggested influences the activity of the serotonergic, noradrenergic and dopaminergic pathways. In the last few years, it has been hypothesized that BDNF level is related with depression and sleep. Several studies show that depressive subjects present low levels of BDNF in the brain. Poor sleep quality is also related with alterations in the BDNF concentration. Some authors argue that most of the cases show that impaired sleep quality increases the stress and, consequently, the vulnerability to depressive disorders, suggesting that there is a relationship between sleep, depression and BDNF levels.",

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AU - Monteiro, Bárbara C.

AU - Monteiro, Suzana

AU - Candida, Maristela

AU - Adler, Nathalia

AU - Paes, Flavia

AU - Rocha, Nuno

AU - Nardi, Antonio Egidio

AU - Murillo-Rodriguez, Eric

AU - Machado, Sergio

PY - 2017/11/1

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N2 - The Brain-Derived Neurotrofic Factor (BDNF) is one of the most important neurotrophins in the brain and it is suggested influences the activity of the serotonergic, noradrenergic and dopaminergic pathways. In the last few years, it has been hypothesized that BDNF level is related with depression and sleep. Several studies show that depressive subjects present low levels of BDNF in the brain. Poor sleep quality is also related with alterations in the BDNF concentration. Some authors argue that most of the cases show that impaired sleep quality increases the stress and, consequently, the vulnerability to depressive disorders, suggesting that there is a relationship between sleep, depression and BDNF levels.

AB - The Brain-Derived Neurotrofic Factor (BDNF) is one of the most important neurotrophins in the brain and it is suggested influences the activity of the serotonergic, noradrenergic and dopaminergic pathways. In the last few years, it has been hypothesized that BDNF level is related with depression and sleep. Several studies show that depressive subjects present low levels of BDNF in the brain. Poor sleep quality is also related with alterations in the BDNF concentration. Some authors argue that most of the cases show that impaired sleep quality increases the stress and, consequently, the vulnerability to depressive disorders, suggesting that there is a relationship between sleep, depression and BDNF levels.

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KW - Bdnf studies

KW - Depression

KW - Sleep

KW - Sleep quality

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Relationship between brain-derived neurotrofic factor (Bdnf) and sleep on depression: A critical review

Abstract

Keywords

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