Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat

Stephanie Mijangos-Moreno; Alwin Poot-Aké; Khalil Guzmán; Gloria Arankowsky-Sandoval; Oscar Arias-Carrión; Jaime Zaldívar-Rae; Andrea Sarro-Ramírez; Eric Murillo-Rodríguez

doi:10.1016/j.neures.2015.09.005

Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat

Stephanie Mijangos-Moreno, Alwin Poot-Aké, Khalil Guzmán, Gloria Arankowsky-Sandoval, Oscar Arias-Carrión, Jaime Zaldívar-Rae, Andrea Sarro-Ramírez, Eric Murillo-Rodríguez

Anahuac Mayab University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10 μg/1 μL; PPARα agonist) enhanced wakefulness and decreased slow wave sleep and rapid eye movement sleep whereas MK-886 (10 μg/1 μL; PPARα antagonist) promoted opposite effects. Moreover, Wy14643 increased dopamine, norepinephrine, serotonin, and adenosine contents collected from nucleus accumbens. The levels of these neurochemicals were diminished after MK-886 treatment. The current findings suggest that PPARα may participate in the sleep and neurochemical modulation.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	Neuroscience Research
Volume	105
DOIs	https://doi.org/10.1016/j.neures.2015.09.005
State	Published - 1 Apr 2016

Keywords

Adenosine
Dopamine
HPLC
Microdialysis
Serotonin
Waking

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10.1016/j.neures.2015.09.005

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title = "Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat",

abstract = "The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10 μg/1 μL; PPARα agonist) enhanced wakefulness and decreased slow wave sleep and rapid eye movement sleep whereas MK-886 (10 μg/1 μL; PPARα antagonist) promoted opposite effects. Moreover, Wy14643 increased dopamine, norepinephrine, serotonin, and adenosine contents collected from nucleus accumbens. The levels of these neurochemicals were diminished after MK-886 treatment. The current findings suggest that PPARα may participate in the sleep and neurochemical modulation.",

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AU - Mijangos-Moreno, Stephanie

AU - Poot-Aké, Alwin

AU - Guzmán, Khalil

AU - Arankowsky-Sandoval, Gloria

AU - Arias-Carrión, Oscar

AU - Zaldívar-Rae, Jaime

AU - Sarro-Ramírez, Andrea

AU - Murillo-Rodríguez, Eric

PY - 2016/4/1

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AB - The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10 μg/1 μL; PPARα agonist) enhanced wakefulness and decreased slow wave sleep and rapid eye movement sleep whereas MK-886 (10 μg/1 μL; PPARα antagonist) promoted opposite effects. Moreover, Wy14643 increased dopamine, norepinephrine, serotonin, and adenosine contents collected from nucleus accumbens. The levels of these neurochemicals were diminished after MK-886 treatment. The current findings suggest that PPARα may participate in the sleep and neurochemical modulation.

KW - Adenosine

KW - Dopamine

KW - HPLC

KW - Microdialysis

KW - Serotonin

KW - Waking

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SP - 65

EP - 69

JO - Neuroscience Research

JF - Neuroscience Research

ER -

Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat

Abstract

Keywords

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