TY - CHAP
T1 - Sleep disorders and genes
AU - Murillo-Rodríguez, Eric
AU - Yamamoto, Tetsuya
AU - Veras, André Barciela
AU - Rocha, Nuno Barbosa
AU - Telles-Correira, Diogo
AU - Machado, Sérgio
AU - Monteiro, Diogo
AU - Budde, Henning
AU - Torterolo, Pablo
N1 - Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24-hour day-night cycle. The sleep-wake cycle is under the control of diverse neuroanatomical and neurochemical systems, including monoaminergic, cholinergic, adenosinergic among many other systems. In addition, neuroanatomical centers linked to sleep promotion, such as the hypothalamus, project to the cerebral cortex, subcortical relays, and brainstem. In addition, the sleep-wake cycle has been associated to aberrant features known as sleep disorders. Here, we will discuss the role of specific gene expression on sleep disturbances. Given the expansion of the knowledge in the sleep-wake cycle area, it is indeed ambitious to describe all the genetics involved in the sleep modulation. However, in this chapter we reviewed the current understanding of the sleep disorders and gene expression.
AB - The sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24-hour day-night cycle. The sleep-wake cycle is under the control of diverse neuroanatomical and neurochemical systems, including monoaminergic, cholinergic, adenosinergic among many other systems. In addition, neuroanatomical centers linked to sleep promotion, such as the hypothalamus, project to the cerebral cortex, subcortical relays, and brainstem. In addition, the sleep-wake cycle has been associated to aberrant features known as sleep disorders. Here, we will discuss the role of specific gene expression on sleep disturbances. Given the expansion of the knowledge in the sleep-wake cycle area, it is indeed ambitious to describe all the genetics involved in the sleep modulation. However, in this chapter we reviewed the current understanding of the sleep disorders and gene expression.
KW - CRISPR-cas9
KW - Gene
KW - Insomnia
KW - Narcolepsy
KW - Restless legs syndrome
KW - Sleep-wake cycle
UR - http://www.scopus.com/inward/record.url?scp=85084592171&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-816430-3.00008-7
DO - 10.1016/B978-0-12-816430-3.00008-7
M3 - Capítulo
AN - SCOPUS:85084592171
SP - 143
EP - 158
BT - The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle
PB - Elsevier
ER -