TY - JOUR
T1 - Sleep-inducing factors
AU - García-García, Fabio
AU - Acosta-Peña, Eva
AU - Venebra-Muñoz, Arturo
AU - Murillo-Rodríguez, Eric
PY - 2009/8/1
Y1 - 2009/8/1
N2 - Kuniomi Ishimori and Henri Piéron were the first researchers to introduce the concept and experimental evidence for a chemical factor that would presumably accumulate in the brain during waking and eventually induce sleep. This substance was named hypnotoxin. Currently, the variety of substances which have been shown to alter sleep includes peptides, cytokines, neurotransmitters and some substances of lipidic nature, many of which are well known for their involvement in other biological activities. In this chapter, we describe the sleep-inducing properties of the vasoactive intestinal peptide, prolactin, adenosine and anandamide.
AB - Kuniomi Ishimori and Henri Piéron were the first researchers to introduce the concept and experimental evidence for a chemical factor that would presumably accumulate in the brain during waking and eventually induce sleep. This substance was named hypnotoxin. Currently, the variety of substances which have been shown to alter sleep includes peptides, cytokines, neurotransmitters and some substances of lipidic nature, many of which are well known for their involvement in other biological activities. In this chapter, we describe the sleep-inducing properties of the vasoactive intestinal peptide, prolactin, adenosine and anandamide.
KW - Cannabinoids
KW - Humoral sleep regulation
KW - Purine
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=70350441463&partnerID=8YFLogxK
U2 - 10.2174/187152709788921672
DO - 10.2174/187152709788921672
M3 - Artículo de revisión
C2 - 19689305
AN - SCOPUS:70350441463
SN - 1871-5273
VL - 8
SP - 235
EP - 244
JO - CNS and Neurological Disorders - Drug Targets
JF - CNS and Neurological Disorders - Drug Targets
IS - 4
ER -