Stand alone or join forces? Stem cell therapy for stroke

Diego Incontri Abraham, Melissa Gonzales, Antonio Ibarra, Cesar V. Borlongan

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Introduction: Stroke is a major cause of mortality and disability with a narrow therapeutic window. Stem cell therapy may enhance the stroke recovery. Areas Covered: Regenerative medicine via stem cells stands as a novel therapy for stroke. In particular, bone marrow-derived mesenchymal stem cells (MSCs) have neuroprotective and anti-inflammatory properties that improve brain function after stroke. Here, we discuss the safety, efficacy, and mechanism of action underlying the therapeutic effects of bone marrow-derived MSCs. We also examine the discrepant transplant protocols between preclinical studies and clinical trials. Laboratory studies show the safety and efficacy of bone marrow-derived MSCs in stroke models. However, while safe, MSCs remain to be fully evaluated as effective in clinical trials. Furthermore, recognizing the multiple cell death processes associated with stroke, we next discuss the potential therapeutic benefits of a combination therapy. With preliminary results and on-going clinical trials, a careful assessment of dosing, timing, and delivery route regimens will further direct the future of stem cell therapy for neurological disorders, including stroke. Expert Opinion: Bone marrow-derived MSCs appear to be the optimal stem cell source for stroke therapy. Optimizing dosing, timing, and delivery route should guide the clinical application of bone marrow-derived MSCs.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalExpert Opinion on Biological Therapy
Volume19
Issue number1
DOIs
StatePublished - 2 Jan 2019

Keywords

  • cell transplantation
  • Cerebral ischemia
  • neurogenesis
  • regenerative medicine

Fingerprint

Dive into the research topics of 'Stand alone or join forces? Stem cell therapy for stroke'. Together they form a unique fingerprint.

Cite this