TY - JOUR
T1 - The emerging role of the endocannabinoid system in the sleep-wake cycle modulation
AU - Murillo-Rodríguez, Eric
AU - Poot-Ake, Alwin
AU - Arias-Carrión, Oscar
AU - Pacheco-Pantoja, Elda
AU - de la Fuente-Ortegón, Alfredo
AU - Arankowsky-Sandoval, Gloria
PY - 2011/1/1
Y1 - 2011/1/1
N2 - The endocannabinoid system comprises amides, esters and ethers of long chain polyunsaturated fatty acids. N-arachidonoylethanolamide (anandamide; ANA) and 2-arachidonoylglycerol (2-AG) are endogenous cannabinoids (endo-cannabinoids) ligands for the cannabinoid family of G-protein-coupled receptors named CB1 and CB2. Endocannabinoids are released upon demand from lipid precursors in a receptor-dependent manner and behave as retrograde signaling messengers, as well as modulators of postsynaptic transmission, interacting with other neurotransmitters systems. The two principal enzymes that are responsible for the metabolism of ANA and 2-AG are fatty acid amide hydrolase and monoa-cylglycerol lipase, respectively. Pharmacological experiments have shown that the administration of endocannabinoids induce cannabimimetic effects, including sleep promotion. This review will focus on some of the current evidence of the pharmacological potential of the endocannabinoid system on sleep modulation.
AB - The endocannabinoid system comprises amides, esters and ethers of long chain polyunsaturated fatty acids. N-arachidonoylethanolamide (anandamide; ANA) and 2-arachidonoylglycerol (2-AG) are endogenous cannabinoids (endo-cannabinoids) ligands for the cannabinoid family of G-protein-coupled receptors named CB1 and CB2. Endocannabinoids are released upon demand from lipid precursors in a receptor-dependent manner and behave as retrograde signaling messengers, as well as modulators of postsynaptic transmission, interacting with other neurotransmitters systems. The two principal enzymes that are responsible for the metabolism of ANA and 2-AG are fatty acid amide hydrolase and monoa-cylglycerol lipase, respectively. Pharmacological experiments have shown that the administration of endocannabinoids induce cannabimimetic effects, including sleep promotion. This review will focus on some of the current evidence of the pharmacological potential of the endocannabinoid system on sleep modulation.
KW - Anandamide
KW - Cannabidiol
KW - Cannabinoid receptors
KW - Cannabinoids
KW - Rapid eye movement sleep
KW - VDM-11
UR - http://www.scopus.com/inward/record.url?scp=80155210179&partnerID=8YFLogxK
U2 - 10.2174/187152411798047780
DO - 10.2174/187152411798047780
M3 - Artículo de revisión
AN - SCOPUS:80155210179
SN - 1871-5249
VL - 11
SP - 189
EP - 196
JO - Central Nervous System Agents in Medicinal Chemistry
JF - Central Nervous System Agents in Medicinal Chemistry
IS - 3
ER -