TY - JOUR
T1 - Toxoplasmosis congénita en el valle de méxico. Resultados de una serie de casos
AU - Gómez-Toscano, Valeria
AU - Linares-López, Karen Alejandra
AU - Arce-Estrada, Gabriel Emmanuel
AU - Figueroa-Damián, Ricardo
AU - Barrios-Bautista, Diana Miriam
AU - Hernández-Luengas, Liliana
AU - Bonilla-Ríos, Christian Alejandro
AU - Tecuátl-Herrada, Blanca Luz
AU - Luna-Pastén, Héctor
AU - Macías-Parra, Mercedes
AU - Cañedo-Solares, Irma
AU - Saltigeral-Simentel, Patricia
AU - Ortiz-Alegría, Luz Belinda
AU - Bosch-Canto, Vanesa
AU - Rico-Torres, Claudia Patricia
AU - Ordaz-Favila, Juan Carlos
AU - Vargas-Villavicencio, José Antonio
AU - López-Candiani, Carlos
AU - Xicoténcatl-García, Lizbeth
AU - Hernández-Antúnez, Blanca Gloria
AU - Ruiz-García, Matilde
AU - Escobedo-Torres, Mónica Patricia
AU - Rivera-González, Iván Rolando
AU - González-González, Luis Oscar
AU - Mora-González, Juan Carlos
AU - Paredes-Alonzo, Iris Evelin
AU - Flores-Lechuga, Ana María
AU - Delgado, Lorena Hernández
AU - Correa, Dolores
N1 - Publisher Copyright:
© Instituto Nacional de Pediatria 2018. All rights reserved.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - BACKGROUND. In Mexico “virulent” strains of Toxoplasma gondii prevail, so the clinical picture may be different to that reported for regions where non-virulent strains are present, such as Europe, United States and Canada. METHODS. We report a series of children with congenital toxoplasmosis recruited since 2005 by prenatal or postnatal screening, or because they arrived as clinical cases at the INP. RESULTS. All the patients presented clinical manifestations, but the prenatal screening group presented a more localized and less severe infection, mainly with spasticity and mild psychomotor retardation. The postnatal screen group presented intermediate clinical characteristics, with mild, moderate or severe psychomotor retardation, low birth weight, micro or hydrocephalus, jaundice, hepatomegaly, splenomegaly, intracranial calcifications and spasticity. The most affected patients were those that presented as clinical cases, with a wide variety of clinical manifestations and the worst prognosis, including death. Six patients presented comorbidities. Twenty cases were positive for two or more laboratory tests; the rest only for one. CONCLUSIONS. Our results support that congenital toxoplasmosis in Mexico is more serious than in other countries, and that it is urgent to implement effective prenatal screening for prevention and prophylaxis.
AB - BACKGROUND. In Mexico “virulent” strains of Toxoplasma gondii prevail, so the clinical picture may be different to that reported for regions where non-virulent strains are present, such as Europe, United States and Canada. METHODS. We report a series of children with congenital toxoplasmosis recruited since 2005 by prenatal or postnatal screening, or because they arrived as clinical cases at the INP. RESULTS. All the patients presented clinical manifestations, but the prenatal screening group presented a more localized and less severe infection, mainly with spasticity and mild psychomotor retardation. The postnatal screen group presented intermediate clinical characteristics, with mild, moderate or severe psychomotor retardation, low birth weight, micro or hydrocephalus, jaundice, hepatomegaly, splenomegaly, intracranial calcifications and spasticity. The most affected patients were those that presented as clinical cases, with a wide variety of clinical manifestations and the worst prognosis, including death. Six patients presented comorbidities. Twenty cases were positive for two or more laboratory tests; the rest only for one. CONCLUSIONS. Our results support that congenital toxoplasmosis in Mexico is more serious than in other countries, and that it is urgent to implement effective prenatal screening for prevention and prophylaxis.
KW - Clinical heterogeneity
KW - Congenital toxoplasmosis
KW - Diagnostic complexity
KW - Postnatal screening
KW - Prenatal evaluation
KW - Prenatal screening
KW - Toxoplasma gondii
UR - http://www.scopus.com/inward/record.url?scp=85057954263&partnerID=8YFLogxK
U2 - 10.18233/apm39no6pp321-3331730
DO - 10.18233/apm39no6pp321-3331730
M3 - Artículo
AN - SCOPUS:85057954263
SN - 0186-2391
VL - 39
SP - 321
EP - 333
JO - Acta Pediatrica de Mexico
JF - Acta Pediatrica de Mexico
IS - 6
ER -