Toxoplasmosis congénita en el valle de méxico. Resultados de una serie de casos

Translated title of the contribution: Congenital toxoplasmosis in the valley of Mexico. Results of a series of cases

Valeria Gómez-Toscano, Karen Alejandra Linares-López, Gabriel Emmanuel Arce-Estrada, Ricardo Figueroa-Damián, Diana Miriam Barrios-Bautista, Liliana Hernández-Luengas, Christian Alejandro Bonilla-Ríos, Blanca Luz Tecuátl-Herrada, Héctor Luna-Pastén, Mercedes Macías-Parra, Irma Cañedo-Solares, Patricia Saltigeral-Simentel, Luz Belinda Ortiz-Alegría, Vanesa Bosch-Canto, Claudia Patricia Rico-Torres, Juan Carlos Ordaz-Favila, José Antonio Vargas-Villavicencio, Carlos López-Candiani, Lizbeth Xicoténcatl-García, Blanca Gloria Hernández-AntúnezMatilde Ruiz-García, Mónica Patricia Escobedo-Torres, Iván Rolando Rivera-González, Luis Oscar González-González, Juan Carlos Mora-González, Iris Evelin Paredes-Alonzo, Ana María Flores-Lechuga, Lorena Hernández Delgado, Dolores Correa

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

BACKGROUND. In Mexico “virulent” strains of Toxoplasma gondii prevail, so the clinical picture may be different to that reported for regions where non-virulent strains are present, such as Europe, United States and Canada. METHODS. We report a series of children with congenital toxoplasmosis recruited since 2005 by prenatal or postnatal screening, or because they arrived as clinical cases at the INP. RESULTS. All the patients presented clinical manifestations, but the prenatal screening group presented a more localized and less severe infection, mainly with spasticity and mild psychomotor retardation. The postnatal screen group presented intermediate clinical characteristics, with mild, moderate or severe psychomotor retardation, low birth weight, micro or hydrocephalus, jaundice, hepatomegaly, splenomegaly, intracranial calcifications and spasticity. The most affected patients were those that presented as clinical cases, with a wide variety of clinical manifestations and the worst prognosis, including death. Six patients presented comorbidities. Twenty cases were positive for two or more laboratory tests; the rest only for one. CONCLUSIONS. Our results support that congenital toxoplasmosis in Mexico is more serious than in other countries, and that it is urgent to implement effective prenatal screening for prevention and prophylaxis.

Translated title of the contributionCongenital toxoplasmosis in the valley of Mexico. Results of a series of cases
Original languageSpanish
Pages (from-to)321-333
Number of pages13
JournalActa Pediatrica de Mexico
Volume39
Issue number6
DOIs
StatePublished - 1 Nov 2018
Externally publishedYes

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