TY - GEN
T1 - Voronoi 3D
T2 - 46th Mexican Conference on Biomedical Engineering, CNIB 2023
AU - Ana Paola, Salgado Alvarez
AU - Alberto, Hernández Vega Luis
AU - Rafael, Alanís Gómez José
AU - Fabiola, Hernández Rosas
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Bone repair is one of the most studied fields within tissue engineering since it is one of the most affected structures in the human body. Biomaterials based on calcium phosphate such as hydroxyapatite (HAp) have demonstrated to be promising solutions, due to its capacity to mimic the mineral composition and/or its porous structure. Additionally, using additive manufacturing alongside Computer-Aided Design Software, has granted the opportunity to generate cellular scaffolds for replacement or bone grafts thanks to its controllable mechanical properties, porosity, pore size and structural form. For this reason, the aim of this project is to design, fabricate and characterize PLA/HAp 3D printed scaffolds for tissue engineering applications. For this, HAp was first synthesized through the Microwave-Assisted Hydrothermal Method using Ca(NO3)2, K2(HPO4) and KOH as precursor and glutamic acid as growth inhibitor, obtaining HAp nanofibers with a hexagonal structure enhancing its mechanical properties. Furthermore, these HAp nanofibers were characterized by X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) to find out the dimension, morphology, topology, orientation, and crystalline structure of the nanofibers. In addition, a variety of 3D bone scaffolds with defined and interconnected pores mimicking the morphology and permeability of the trabecular bone, were designed using 3D Voronoi tessellation method through Rhinoceros 7 with Grasshopper. These scaffolds were fabricated using the extrusion method, where PLA was melted and extruded as a filament. Layer by layer the filament was deposited to create scaffolds with a controlled arrangement of struts and pore dimensions without the need for a binder.
AB - Bone repair is one of the most studied fields within tissue engineering since it is one of the most affected structures in the human body. Biomaterials based on calcium phosphate such as hydroxyapatite (HAp) have demonstrated to be promising solutions, due to its capacity to mimic the mineral composition and/or its porous structure. Additionally, using additive manufacturing alongside Computer-Aided Design Software, has granted the opportunity to generate cellular scaffolds for replacement or bone grafts thanks to its controllable mechanical properties, porosity, pore size and structural form. For this reason, the aim of this project is to design, fabricate and characterize PLA/HAp 3D printed scaffolds for tissue engineering applications. For this, HAp was first synthesized through the Microwave-Assisted Hydrothermal Method using Ca(NO3)2, K2(HPO4) and KOH as precursor and glutamic acid as growth inhibitor, obtaining HAp nanofibers with a hexagonal structure enhancing its mechanical properties. Furthermore, these HAp nanofibers were characterized by X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) to find out the dimension, morphology, topology, orientation, and crystalline structure of the nanofibers. In addition, a variety of 3D bone scaffolds with defined and interconnected pores mimicking the morphology and permeability of the trabecular bone, were designed using 3D Voronoi tessellation method through Rhinoceros 7 with Grasshopper. These scaffolds were fabricated using the extrusion method, where PLA was melted and extruded as a filament. Layer by layer the filament was deposited to create scaffolds with a controlled arrangement of struts and pore dimensions without the need for a binder.
KW - 3D printing
KW - Biomaterial
KW - Bone Scaffolds
KW - Hydroxyapatite
UR - http://www.scopus.com/inward/record.url?scp=85177468196&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-46936-7_13
DO - 10.1007/978-3-031-46936-7_13
M3 - Contribución a la conferencia
AN - SCOPUS:85177468196
SN - 9783031469350
T3 - IFMBE Proceedings
SP - 122
EP - 130
BT - 46th Mexican Conference on Biomedical Engineering - Proceedings of CNIB 2023 - Volume 2
A2 - Flores Cuautle, José de Jesús Agustín
A2 - Benítez-Mata, Balam
A2 - Salido-Ruiz, Ricardo Antonio
A2 - Vélez-Pérez, Hugo A.
A2 - Alonso-Silverio, Gustavo Adolfo
A2 - Dorantes-Méndez, Guadalupe
A2 - Mejía-Rodríguez, Aldo Rodrigo
A2 - Zúñiga-Aguilar, Esmeralda
A2 - Hierro-Gutiérrez, Edgar Del
PB - Springer Science and Business Media Deutschland GmbH
Y2 - 2 November 2023 through 4 November 2023
ER -