Voronoi 3D: A Novel Approach to Design 3D PLA/HAp Printed Scaffolds for Tissue Engineering Applications

Salgado Alvarez Ana Paola, Hernández Vega Luis Alberto, Alanís Gómez José Rafael, Hernández Rosas Fabiola

Risultato della ricercapeer review

Abstract

Bone repair is one of the most studied fields within tissue engineering since it is one of the most affected structures in the human body. Biomaterials based on calcium phosphate such as hydroxyapatite (HAp) have demonstrated to be promising solutions, due to its capacity to mimic the mineral composition and/or its porous structure. Additionally, using additive manufacturing alongside Computer-Aided Design Software, has granted the opportunity to generate cellular scaffolds for replacement or bone grafts thanks to its controllable mechanical properties, porosity, pore size and structural form. For this reason, the aim of this project is to design, fabricate and characterize PLA/HAp 3D printed scaffolds for tissue engineering applications. For this, HAp was first synthesized through the Microwave-Assisted Hydrothermal Method using Ca(NO3)2, K2(HPO4) and KOH as precursor and glutamic acid as growth inhibitor, obtaining HAp nanofibers with a hexagonal structure enhancing its mechanical properties. Furthermore, these HAp nanofibers were characterized by X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) to find out the dimension, morphology, topology, orientation, and crystalline structure of the nanofibers. In addition, a variety of 3D bone scaffolds with defined and interconnected pores mimicking the morphology and permeability of the trabecular bone, were designed using 3D Voronoi tessellation method through Rhinoceros 7 with Grasshopper. These scaffolds were fabricated using the extrusion method, where PLA was melted and extruded as a filament. Layer by layer the filament was deposited to create scaffolds with a controlled arrangement of struts and pore dimensions without the need for a binder.

Lingua originaleEnglish
Titolo della pubblicazione ospite46th Mexican Conference on Biomedical Engineering - Proceedings of CNIB 2023 - Volume 2
Sottotitolo della pubblicazione ospiteBiomechanics, Rehabilitation and Clinical Engineering
EditorJosé de Jesús Agustín Flores Cuautle, Balam Benítez-Mata, Ricardo Antonio Salido-Ruiz, Hugo A. Vélez-Pérez, Gustavo Adolfo Alonso-Silverio, Guadalupe Dorantes-Méndez, Aldo Rodrigo Mejía-Rodríguez, Esmeralda Zúñiga-Aguilar, Edgar Del Hierro-Gutiérrez
EditoreSpringer Science and Business Media Deutschland GmbH
Pagine122-130
Numero di pagine9
ISBN (stampa)9783031469350
DOI
Stato di pubblicazionePublished - 1 gen 2024
Evento46th Mexican Conference on Biomedical Engineering, CNIB 2023 - Villahermosa Tabasco
Durata: 2 nov 20234 nov 2023

Serie di pubblicazioni

NomeIFMBE Proceedings
Volume97
ISSN (stampa)1680-0737
ISSN (elettronico)1433-9277

Conference

Conference46th Mexican Conference on Biomedical Engineering, CNIB 2023
Paese/TerritorioMexico
CittàVillahermosa Tabasco
Periodo2/11/234/11/23

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